Abstract
Alzheimers disease (AD) is a common cause of dementia, resulting from accumulated β-amyloid protein deposits in the brain. As the population ages the incidence of AD is also on the rise. The incidence is very high in the developed countries where life expectancy is high, but it is also rising rapidly in the developing countries. Caring for patients suffering from AD is a major economic burden. The mechanisms underlying the neuropathology of AD are slowly being unravelled. Here we explore the many models and theories, which have been proposed over the years. We then discuss a potential therapeutic agent, vaccinia virus complement control protein (VCP), involved in modulating the complement system in AD. VCP has been shown in in vitro studies to block the complement activation caused by the beta peptide. Traumatic injuries to the brain are well known risk factors associated with the development of AD. VCP can also enhance functional recovery resulting from traumatic brain injury and may be able to slow the progression of traumatic brain injury to AD. Here we describe strategies for testing this hypothesis and evaluating other agents such as VCP.
Keywords: traumatic brain injury, amyloid, tau, vaccinia virus complement control protein, fluid percussion injury, nucleus basalis magnocellularis, lentivirus
Current Alzheimer Research
Title: Molecular Mechanisms, Emerging Etiological Insights and Models to Test Potential Therapeutic Interventions in Alzheimers Disease
Volume: 1 Issue: 4
Author(s): Nirvana S. Pillay, Laurie A. Kellaway and Girish J. Kotwal
Affiliation:
Keywords: traumatic brain injury, amyloid, tau, vaccinia virus complement control protein, fluid percussion injury, nucleus basalis magnocellularis, lentivirus
Abstract: Alzheimers disease (AD) is a common cause of dementia, resulting from accumulated β-amyloid protein deposits in the brain. As the population ages the incidence of AD is also on the rise. The incidence is very high in the developed countries where life expectancy is high, but it is also rising rapidly in the developing countries. Caring for patients suffering from AD is a major economic burden. The mechanisms underlying the neuropathology of AD are slowly being unravelled. Here we explore the many models and theories, which have been proposed over the years. We then discuss a potential therapeutic agent, vaccinia virus complement control protein (VCP), involved in modulating the complement system in AD. VCP has been shown in in vitro studies to block the complement activation caused by the beta peptide. Traumatic injuries to the brain are well known risk factors associated with the development of AD. VCP can also enhance functional recovery resulting from traumatic brain injury and may be able to slow the progression of traumatic brain injury to AD. Here we describe strategies for testing this hypothesis and evaluating other agents such as VCP.
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Cite this article as:
Pillay S. Nirvana, Kellaway A. Laurie and Kotwal J. Girish, Molecular Mechanisms, Emerging Etiological Insights and Models to Test Potential Therapeutic Interventions in Alzheimers Disease, Current Alzheimer Research 2004; 1 (4) . https://dx.doi.org/10.2174/1567205043331965
DOI https://dx.doi.org/10.2174/1567205043331965 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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