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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back

Author(s): A. Alberici, M. Cosseddu, A. Padovani and B. Borroni

Volume 8, Issue 3, 2011

Page: [229 - 236] Pages: 8

DOI: 10.2174/156720511795563737

Price: $65

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Abstract

Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.

Keywords: Fronto temporal lobak degeneration, MAPT, progranulin, DLDH, PNFA, CBS, PSP, frontal atrophy, FTLD-MND, CHMP2B, language dysfunction, (TAR)-DNA-binding, NCI, ALS


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