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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

α-Synuclein Aggregation

Author(s): Angela M. Bodles and G. Brent Irvine

Volume 11, Issue 3, 2004

Page: [271 - 279] Pages: 9

DOI: 10.2174/0929866043407084

Price: $65

Abstract

α-Synuclein is a major component of Lewy bodies in Parkinsons disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

Keywords: synuclein, amyloid, aggregation, parkinsons disease


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