Abstract
Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the removal of ubiquitin, which is performed by deubiquitinating enzymes (DUBs). While it has been appreciated for some 10 years that DUBs constitute large gene families in eukaryotes, and known for much longer that ubiquitination is a reversible process, information on the exact role of DUBs has been slow in coming. This review will attempt to summarise results from the last few years that shows that DUBs are an essential regulatory step of both protein degradation by the proteasome, and of other ubiquitin-dependent processes, by virtue of their ability to regulate protein ubiquitination in a target-specific manner.
Keywords: deubiquitinating enzyme, ubiquitin-specific protease, ubiquitin c-terminal hydrolase, isopeptidase, otu domain, jamm domain
Current Protein & Peptide Science
Title: Deubiquitinating Enzymes: Their Functions and Substrate Specificity
Volume: 5 Issue: 3
Author(s): Tatiana A. Soboleva and Rohan T. Baker
Affiliation:
Keywords: deubiquitinating enzyme, ubiquitin-specific protease, ubiquitin c-terminal hydrolase, isopeptidase, otu domain, jamm domain
Abstract: Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the removal of ubiquitin, which is performed by deubiquitinating enzymes (DUBs). While it has been appreciated for some 10 years that DUBs constitute large gene families in eukaryotes, and known for much longer that ubiquitination is a reversible process, information on the exact role of DUBs has been slow in coming. This review will attempt to summarise results from the last few years that shows that DUBs are an essential regulatory step of both protein degradation by the proteasome, and of other ubiquitin-dependent processes, by virtue of their ability to regulate protein ubiquitination in a target-specific manner.
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Cite this article as:
Soboleva A. Tatiana and Baker T. Rohan, Deubiquitinating Enzymes: Their Functions and Substrate Specificity, Current Protein & Peptide Science 2004; 5 (3) . https://dx.doi.org/10.2174/1389203043379765
DOI https://dx.doi.org/10.2174/1389203043379765 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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