Title: Celiac Disease: An Emerging Epidemic
Volume: 1
Issue: 3
Author(s): Peter H.R. Green and Anne R. Lee
Affiliation:
Keywords:
gluten sensitive enteropathy, HLA-DQ2, IgA endomysial antibody, gluten-free diet, autoimmune diseases, Selective IgA deficiency
Abstract: Celiac disease is a genetically determined autoimmune disorder induced by an environmental agent, gluten. The disease involves the development of a T-cell mediated inflammatory reaction to ingested gluten in the small intestine that results in villous atrophy. The manifestations of the disease are varied. Patients may be critically ill due to a severe malabsorption syndrome or asymptomatic. The reason for the varied phenotypic expression of the disease is unclear. The mainstay of therapy is a gluten-free diet that may be a testing endeavor in this culture.