Generic placeholder image

Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

C-1073 (Mifepristone) in the Adjunctive Treatment of Alzheimers Disease

Author(s): Charles DeBattista and Joseph Belanoff

Volume 2, Issue 2, 2005

Page: [125 - 129] Pages: 5

DOI: 10.2174/1567205053585954

Price: $65

Open Access Journals Promotions 2
Abstract

Alzheimers disease is frequently associated with abnormalities in the hypothalamic pituitary adrenal axis. Elevated cortisol levels in Alzheimers disease may in turn be associated with a more rapid progression of the illness. In addition, elevated cortisol levels may directly contribute to cognitive deficits in Alzheimers disease. Mifepristone is a potent antagonist of the glucocorticoid receptor and blocks the central actions of cortisol. The purpose of this study is to determine the effects of glucocorticoid receptor blockade with mifepristone on cognition in Alzheimers disease.

Keywords: glucocorticoid II receptor, hypothalamic pituitary adrenal (hpa), psychotic major depression (pmd), hippocampus, progesterone, transcription, dna, cushing, , s disease, hypercortisolemia, bipolar affective disorder


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy