Title: Analysis of Monomeric Mutants of HSC70: A Possible Relationship Between Oligomerization and Functional Properties
Volume: 14
Issue: 8
Author(s): Mouna Amor-Mahjoub, Nathalie Gomez-Vrielyunck, Jean Philippe Suppini, Benoit Fouchaq, Nadia Benaroudj and Moncef Ladjimi
Affiliation:
Keywords:
HSC70, Mutagenesis, Oligomerization, Ultracentrifugation, ATPase activity
Abstract: Data of this study showed that αD-αE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
