Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides

Title: Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides

Volume: 4 Issue: 6

Author(s): Carla Veronica B. dos S. Canuto, Claudia R. B. Gomes, Isakelly P. Marques, Leticia V. Faro, Fernanda da Costa Santos, Izabel Christina de P. P. Frugulhetti, Thiago M. L. e Souza, Anna C.Cunha, Gilberto A. Romeiro, Vitor F. Ferreira and Maria Cecilia B.V.de Souza

Affiliation:

Keywords: Nucleosides, Oxoquinolineribonucleosides, Anti-HSV-1

Abstract: Oxoquinolineribonucleosides 1a-j were prepared. These substances were screened for antiviral activity on HSV-1 virus infection, assessed by virus yield assay. The chlorosubstituted ribonucleosides 1b and 1g were the best inhibitors of HSV-1 yield with EC50 of 1.5 ± 0.06 μM and 1.7 ± 0.08 μM, respectively. Compound 1b presented the best selectivity index (SI) with an SI value of 1000.

Cite this article as:

Carla Veronica B. dos S. Canuto , Claudia R. B. Gomes , Isakelly P. Marques , Leticia V. Faro , Fernanda da Costa Santos , Izabel Christina de P. P. Frugulhetti , Thiago M. L. e Souza , Anna C.Cunha , Gilberto A. Romeiro , Vitor F. Ferreira and Maria Cecilia B.V.de Souza , Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides, Letters in Drug Design & Discovery 2007; 4 (6) . https://dx.doi.org/10.2174/157018007781387818