A Simple and Efficient Synthesis of (S)- and (R)-1-(3-Methoxyphenyl) Ethylamine

Title: A Simple and Efficient Synthesis of (S)- and (R)-1-(3-Methoxyphenyl) Ethylamine

Volume: 4 Issue: 2

Author(s): Meng Hu, Fu-Li Zhang and Mei-Hua Xie

Affiliation:

Keywords: (S)-1-(3-methoxyphenyl)ethylamine, (R)-1-(3-methoxyphenyl)ethylamine, asymmetric reductive amination, synthesis

Abstract: A novel one-pot asymmetric reductive amination of 3-methoxyacetophenone with (S)- or (R)-α- methylbenzylamine using the combination of Ti(OiPr)4/Raney-Ni/H2 has been reported. This procedure provides excellent yield and diastereomeric excess. After cleaving the chiral auxiliary, (S)- or (R)-1-(3- methoxyphenyl)ethylamine was obtained in high yield.

Cite this article as:

Hu Meng, Zhang Fu-Li and Xie Mei-Hua, A Simple and Efficient Synthesis of (S)- and (R)-1-(3-Methoxyphenyl) Ethylamine, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414190