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Abstract
Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.
Keywords: Neurodegenerative diseases, Lipoic acid, Antioxidants, Multi-target-directed drugs, Reactive oxygen species
Mini-Reviews in Medicinal Chemistry
Title: Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration
Volume: 6 Issue: 11
Author(s): Maria L. Bolognesi, Anna Minarini, Vincenzo Tumiatti and Carlo Melchiorre
Affiliation:
Keywords: Neurodegenerative diseases, Lipoic acid, Antioxidants, Multi-target-directed drugs, Reactive oxygen species
Abstract: Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.
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Cite this article as:
Bolognesi L. Maria, Minarini Anna, Tumiatti Vincenzo and Melchiorre Carlo, Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742731
DOI https://dx.doi.org/10.2174/138955706778742731 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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