Title: Adenosine-to-Inosine RNA Editing: Perspectives and Predictions
Volume: 6
Issue: 11
Author(s): Barry Hoopengardner
Affiliation:
Keywords:
Adenosine, inosine, RNA, editing, drosophila, ion channel, convergence
Abstract: Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.