Title: Selective Agents for Serotonin2C (5-HT2C) Receptor
Volume: 6
Issue: 18
Author(s): Enza Lacivita and Marcello Leopoldo
Affiliation:
Keywords:
CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Abstract: The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.
