Abstract
A series of mono- and bis-pyrimido-[1,2-a]benzimidazole derivatives is synthesized by the regioselective multicomponent condensation reaction of aldehyde and malononitrile with 2-aminobenzimidazole in the presence of alum as a recyclable and efficient catalyst for this condensation.
Keywords: 2-Aminobenzimidazole, alum, multicomponent reaction, pyrimido[1,2-a]benzimidazole, regioselectivity, benzo-fused imidazoles, anticancer, antihistaminic, antifungal, antibacterial
Letters in Organic Chemistry
Title: Mono- and Bis-Pyrimido[1,2-a]benzimidazoles: Alum Catalyzed Regioselective Three- or Pseudo Five-Component Reaction of 2-Aminobenzimidazole with Aldehyde and Malononitrile
Volume: 8 Issue: 9
Author(s): Ali R. Karimi and Fahimeh Bayat
Affiliation:
Keywords: 2-Aminobenzimidazole, alum, multicomponent reaction, pyrimido[1,2-a]benzimidazole, regioselectivity, benzo-fused imidazoles, anticancer, antihistaminic, antifungal, antibacterial
Abstract: A series of mono- and bis-pyrimido-[1,2-a]benzimidazole derivatives is synthesized by the regioselective multicomponent condensation reaction of aldehyde and malononitrile with 2-aminobenzimidazole in the presence of alum as a recyclable and efficient catalyst for this condensation.
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Cite this article as:
R. Karimi Ali and Bayat Fahimeh, Mono- and Bis-Pyrimido[1,2-a]benzimidazoles: Alum Catalyzed Regioselective Three- or Pseudo Five-Component Reaction of 2-Aminobenzimidazole with Aldehyde and Malononitrile, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304368
DOI https://dx.doi.org/10.2174/157017811799304368 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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