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Current Cancer Therapy Reviews

Editor-in-Chief

ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

Mastocytosis

Author(s): Tracy I. George

Volume 8, Issue 1, 2012

Page: [35 - 43] Pages: 9

DOI: 10.2174/157339412799462549

Price: $65

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Abstract

Mastocytosis or mast cell disease represents a clonal, neoplastic proliferation of mast cells that can present in one or multiple organs, varying from indolent to aggressive disorders in adult and pediatric patients. This review presents the definition of the various forms of mastocytosis along with the characteristic cytomorphological, immunophenotypic, cytogenetic, and molecular features and discusses in depth the differential diagnoses. Following this presentation, the review then focuses on therapeutic approaches, including targeted therapy.

Keywords: Mastocytosis, D816V KIT


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