Purification and Properties of Laticeptin, an Antimicrobial Peptide from Skin Secretions of the South American Frog Leptodactylus laticeps

Title: Purification and Properties of Laticeptin, an Antimicrobial Peptide from Skin Secretions of the South American Frog Leptodactylus laticeps

Volume: 13 Issue: 4

Author(s): J. M. Conlon, Nadia Al-Ghaferi, Bency Abraham, Agnes Sonnevend, Jay D. King and Per F. Nielsen

Affiliation:

Keywords: Antimicrobial peptide, frog skin, leptodactylidae, laticeptin, fallaxin

Abstract: Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys- Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH2. Laticeptin inhibited the growth of selected Gramnegative bacteria but the lack of activity against Gram-positive bacteria and the very low hemolytic activity is probably a consequence of the weak amphipathicity of the peptide in its a-helical conformation.

Cite this article as:

Conlon M. J., Al-Ghaferi Nadia, Abraham Bency, Sonnevend Agnes, King D. Jay and Nielsen F. Per, Purification and Properties of Laticeptin, an Antimicrobial Peptide from Skin Secretions of the South American Frog Leptodactylus laticeps, Protein & Peptide Letters 2006; 13 (4) . https://dx.doi.org/10.2174/092986606775974410