Title: Electrochemical DNA Sensors: From Nanoconstruction to Biosensing
Volume: 15
Issue: 4
Author(s): Haixin Chang, Ying Wang and Jinghong Li
Affiliation:
Keywords:
Electrochemical, DNA sensor, nanoconstruction, biosensing, optical, microgravimetric, Intercalator, organic dye such as Hoecht, daunomy-cin, ferrocenyl naphthalene diimide, horseradish-peroxidase (HRP), single nucleotide polymorphisms, PSA, Chronocoulometry, ASV, CV, DPV, SWCNTs, Magnetic nanobeads, Metal Nanoparticles, human cytomegalovirus (HCMV) DNA, ferrocene, HBr, H5N1 virus, strepavidin modified magnetic bead, biotin, biotin-avidin interaction, man immunodeficiency virus (HIV), trochemical impedance spectroscopy, electrochemiluminescence (ECL), carbon nanotubes (CNTs), Semiconductor Nanoparticles, signal-off responses, plasma-enhanced chemical vapor deposition (PECVD), phthalo-cyanine, ferrocenecarboxaldehyde, mercaptohexadecanoic acid, folate receptor, multi-walled carbon nanotubes (MWCNTs), Nafion, DNA-mediated electron transfer, Avian influenza, Escherichia coli O157, hepatitis C virus
Abstract: Electrochemical DNA sensors have been increasingly fascinating due to high sensitivity, specificity, portability and integrated compatibilities with microelectronics. Numerous strategies have been developed to design electrochemical DNA sensors with high sensitivity and selectivity. In this review, we will focus on the efforts toward sensitive electrochemical DNA sensing based on nanomaterials including metal nanoparticles, magnetic nanoparticles, semiconductor nanoparticles and carbon nanomaterials, especially carbon nanotubes. The potential application of the electrochemical DNA sensors in gene analysis, diagnosis, environmental and food safety monitoring will be briefly discussed. At the end of this review, we will give a brief outlook of the future challenges of electrochemical DNA sensors.
