Abstract
Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine design has great potential but, so far, remains a largely unproven concept. Further structural information for the envelope (Env) glycoproteins, gp120 and gp41, would be extremely beneficial, particularly for understanding trimer-specific antibodies and their epitopes and to clarify the atomic details of the structural elements responsible for masking crucial epitopes and for mediating the conformational rearrangements undertaken during the process of receptor-binding and membrane fusion.
Keywords: HIV-1 vaccine, broadly neutralizing antibodies, immunogen, HIV-1 envelope, HIV-1 trimer, gp120, gp41, Vaccine, HIV, neutralization, glycoproteins, antibodies, B cell, T cell, anti-retroviral therapy, glycosylation, monoclonal antibodies, cryoelectron tomography, Gly-Ala-Gly, CD4-induced, influenza virus, ebola virus, visna virus, human respiratory syncytial virus, T-lymphotropic virus, leukemia, SIV mac239 trimers, HJ16, VRC01, CD4 binding site, Hyperglycosylation, High-Mannose Glycan Cluster, Z13e1
Current Pharmaceutical Design
Title: Structure-based Vaccine Design in HIV: Blind Men and the Elephant?
Volume: 16 Issue: 33
Author(s): Robert Pejchal and Ian A. Wilson
Affiliation:
Keywords: HIV-1 vaccine, broadly neutralizing antibodies, immunogen, HIV-1 envelope, HIV-1 trimer, gp120, gp41, Vaccine, HIV, neutralization, glycoproteins, antibodies, B cell, T cell, anti-retroviral therapy, glycosylation, monoclonal antibodies, cryoelectron tomography, Gly-Ala-Gly, CD4-induced, influenza virus, ebola virus, visna virus, human respiratory syncytial virus, T-lymphotropic virus, leukemia, SIV mac239 trimers, HJ16, VRC01, CD4 binding site, Hyperglycosylation, High-Mannose Glycan Cluster, Z13e1
Abstract: Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine design has great potential but, so far, remains a largely unproven concept. Further structural information for the envelope (Env) glycoproteins, gp120 and gp41, would be extremely beneficial, particularly for understanding trimer-specific antibodies and their epitopes and to clarify the atomic details of the structural elements responsible for masking crucial epitopes and for mediating the conformational rearrangements undertaken during the process of receptor-binding and membrane fusion.
Export Options
About this article
Cite this article as:
Pejchal Robert and A. Wilson Ian, Structure-based Vaccine Design in HIV: Blind Men and the Elephant?, Current Pharmaceutical Design 2010; 16 (33) . https://dx.doi.org/10.2174/138161210794079173
DOI https://dx.doi.org/10.2174/138161210794079173 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
Current Pharmaceutical Design Editorial (Thematic Issue: Translational Alzheimer’s Disease Research)
Current Alzheimer Research Dopamine Receptor Pharmacology: Interactions with Serotonin Receptors and Significance for the Aetiology and Treatment of Schizophrenia
CNS & Neurological Disorders - Drug Targets Effect of Aging On the Human Kinetic Visual Field
Neuroscience and Biomedical Engineering (Discontinued) The Discovery of VLA-4 Antagonists
Current Topics in Medicinal Chemistry Gestational Programming of Offspring Obesity: A Potential Contributor to Alzheimers Disease
Current Alzheimer Research Automated Radiosynthesis and Molecular Docking Studies of Coumarin- Triazole Hybrid with fluorine-18: A feasibility study
Current Radiopharmaceuticals Isolation and Quantification of Chemical Marker of Polygonatum verticillatum: First Report
Current Traditional Medicine Microglia in Alzheimer’s Disease
Current Alzheimer Research Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review
Current Drug Targets Theory of Mind in the Early Course of Schizophrenia
Current Psychiatry Reviews Impact of Viscosity and Refractive Index on Droplet Size and Zeta Potential of Model O/W and W/O Nanoemulsion
Current Nanoscience Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids
Medicinal Chemistry Neurotoxicity of β-Amyloid Protein: Oligomerization, Channel Formation and Calcium Dyshomeostasis
Current Pharmaceutical Design Roles of miRNA in the Initiation and Development of Colorectal Carcinoma
Current Pharmaceutical Design Common Molecular Targets for Bioactive Food Components and Drugs
Current Pediatric Reviews Paeonol, a Powerful Natural Product with Broad Biological Spectra by Inhibiting Inflammatory Pathway
Current Traditional Medicine Association Study of IL-4 -590 C/T and DDX39B -22 G/C Polymorphisms with the Risk of Late-Onset Alzheimer’s Disease in Iranian Population
Current Aging Science Potential Therapeutic Effects of Na+/Ca2+ Exchanger Inhibition in Cardiac Diseases
Current Medicinal Chemistry Polarization of Calcium Signaling and Fluid Secretion in Salivary Gland Cells
Current Medicinal Chemistry