Title: Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes
Volume: 13
Issue: 6
Author(s): Birke Dejaegher, Sigrid Pieters, Yvan Vander Heyden and Bieke Dejaegher
Affiliation:
Keywords:
Hydrophilic interaction liquid chromatography (HILIC), supercritical fluid chromatography (SFC), polar organic solvent chromatography (POSC)
Abstract: In this review paper, the high throughput potential of some novel chromatographic modes is surveyed. The modes are Hydrophilic Interaction Liquid Chromatography (HILIC), Supercritical Fluid Chromatography (SFC), and Polar Organic Solvent Chromatography (POSC). Their high throughput potential will be discussed in three domains, i.e. drug discovery, bio-analysis in clinical drug development, and quality control (QC) testing, and is illustrated with some examples.