Abstract
An overview of the usefulness of different nanoparticles to improve the features of high throughput separation and individual and multiplexed detection bioassays is presented. Although the development of microarray and microfluidic systems has expanded the capabilities of these high throughput assays, the combined use of NPs and these devices has provided them with new applications in drug discovery, proteomic and genomic studies, and clinical diagnosis. This article reviews the wide application field of magnetic, gold, silver, semiconductor and other nanoparticles in high throughput bioassays. Also, the versatility of the detection systems described shows that NPs are useful alternatives to fluorescent dyes, which are often used in these assays.
Keywords: Nanoparticles, high throughput bioassays, separation and detection methods
Combinatorial Chemistry & High Throughput Screening
Title: High Throughput Bioassays Using Nanoparticles
Volume: 13 Issue: 4
Author(s): Agustina Gomez-Hens, Juan M. Fernandez-Romero and Maria P. Aguilar-Caballos
Affiliation:
Keywords: Nanoparticles, high throughput bioassays, separation and detection methods
Abstract: An overview of the usefulness of different nanoparticles to improve the features of high throughput separation and individual and multiplexed detection bioassays is presented. Although the development of microarray and microfluidic systems has expanded the capabilities of these high throughput assays, the combined use of NPs and these devices has provided them with new applications in drug discovery, proteomic and genomic studies, and clinical diagnosis. This article reviews the wide application field of magnetic, gold, silver, semiconductor and other nanoparticles in high throughput bioassays. Also, the versatility of the detection systems described shows that NPs are useful alternatives to fluorescent dyes, which are often used in these assays.
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Cite this article as:
Gomez-Hens Agustina, M. Fernandez-Romero Juan and P. Aguilar-Caballos Maria, High Throughput Bioassays Using Nanoparticles, Combinatorial Chemistry & High Throughput Screening 2010; 13 (4) . https://dx.doi.org/10.2174/138620710791054240
DOI https://dx.doi.org/10.2174/138620710791054240 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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