Abstract
Exogenous glucocorticoids are commonly used in the treatment of various conditions including asthma, rhinitis, and a range of renal, gastrointestinal and malignant diseases in children. Glucocorticoid treatment has numerous systemic side effects beside the beneficial effects. An important and well described side effect is growth suppression. Knemometry, i.e. measurement of the lower leg length, is a well established method for assessment of short term growth. The present article reviews the role of knemometry in the assessment of growth suppressive effects of glucocorticoid treatment, and the present data on lower leg growth during glucocorticoid treatment are summarized. Our knowledge on the effects of exogenous glucocorticoids in the different components (bones, cartilage, cutis and subcutis, etc.) of the lower leg is reviewed, and integrated with recent studies assessing such effects by new methods.
Keywords: Knemometry, glucocorticoids, lower leg length, lower leg growth, growth suppression, soft tissue component
Current Pediatric Reviews
Title: Knemometry for Assessment of Growth Suppressive Effects of Exogenous Glucocorticoids
Volume: 2 Issue: 1
Author(s): Anders J. Schou
Affiliation:
Keywords: Knemometry, glucocorticoids, lower leg length, lower leg growth, growth suppression, soft tissue component
Abstract: Exogenous glucocorticoids are commonly used in the treatment of various conditions including asthma, rhinitis, and a range of renal, gastrointestinal and malignant diseases in children. Glucocorticoid treatment has numerous systemic side effects beside the beneficial effects. An important and well described side effect is growth suppression. Knemometry, i.e. measurement of the lower leg length, is a well established method for assessment of short term growth. The present article reviews the role of knemometry in the assessment of growth suppressive effects of glucocorticoid treatment, and the present data on lower leg growth during glucocorticoid treatment are summarized. Our knowledge on the effects of exogenous glucocorticoids in the different components (bones, cartilage, cutis and subcutis, etc.) of the lower leg is reviewed, and integrated with recent studies assessing such effects by new methods.
Export Options
About this article
Cite this article as:
Schou J. Anders, Knemometry for Assessment of Growth Suppressive Effects of Exogenous Glucocorticoids, Current Pediatric Reviews 2006; 2 (1) . https://dx.doi.org/10.2174/157339606775518377
DOI https://dx.doi.org/10.2174/157339606775518377 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Preface
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Subject Index To Volume-3
Letters in Drug Design & Discovery Role and Pharmacogenomics of TNF-α in Asthma
Mini-Reviews in Medicinal Chemistry MIF and CD74 - Suitability as Clinical Biomarkers
Mini-Reviews in Medicinal Chemistry Current Developments in the Therapeutic Potential of S-Nitrosoglutathione, an Endogenous NO-Donor Molecule
Current Pharmaceutical Biotechnology Complementary and Alternative Medical Therapies in Fibromyalgia
Current Pharmaceutical Design Predicting Targeted Polypharmacology for Drug Repositioning and Multi- Target Drug Discovery
Current Medicinal Chemistry Effects of Natural Products on Contact Dermatitis
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Editorial (Hot Topic : Computational Prediction of Drug-Target Interactions in Medicinal Chemistry)
Current Topics in Medicinal Chemistry Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics
Current Drug Metabolism Pharmacological Modulation of Th17
Recent Patents on Inflammation & Allergy Drug Discovery Potential of Selected Indian Herbs for COVID-19
Current Traditional Medicine Selected Engineering and Physicochemical Aspects of Systemic Drug Delivery by Inhalation
Current Pharmaceutical Design The Role of the RhoA/rho-kinase Pathway in Pulmonary Hypertension
Current Drug Discovery Technologies Green Tea Polyphenols as an Anti-Oxidant and Anti-Inflammatory Agent for Cardiovascular Protection
Cardiovascular & Hematological Disorders-Drug Targets Cytokine Therapeutics for Asthma: An Appraisal of Current Evidence and Future Prospects
Current Pharmaceutical Design Targeting Soluble Epoxide Hydrolase for Inflammation and Pain - An Overview of Pharmacology and the Inhibitors
Inflammation & Allergy - Drug Targets (Discontinued) Cow’s Milk Allergenicity
Endocrine, Metabolic & Immune Disorders - Drug Targets Meet Our Editorial Board Member
Current Pediatric Reviews Use of Ceramides and Related Products for Childhood-Onset Eczema
Recent Patents on Inflammation & Allergy Drug Discovery