Abstract
The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.
Keywords: Kynurenic acid, kynurenic acid derivatives, neurological disorders, schizophrenia, retinal damage, diabetes mellitus, hypertension
Current Medicinal Chemistry
Title: Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives
Volume: 16 Issue: 36
Author(s): F. Fulop, I. Szatmari, E. Vamos, D. Zadori, J. Toldi and L. Vecsei
Affiliation:
Keywords: Kynurenic acid, kynurenic acid derivatives, neurological disorders, schizophrenia, retinal damage, diabetes mellitus, hypertension
Abstract: The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.
Export Options
About this article
Cite this article as:
Fulop F., Szatmari I., Vamos E., Zadori D., Toldi J. and Vecsei L., Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives, Current Medicinal Chemistry 2009; 16 (36) . https://dx.doi.org/10.2174/092986709789909602
DOI https://dx.doi.org/10.2174/092986709789909602 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Comprehensive Study of <i>Allium Sativum Linn</i>
Current Functional Foods Current Clinical Applications of In Vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging
Current Medical Imaging Antiseizure Medications for the Prophylaxis of Migraine during the Anti- CGRP Drugs Era
Current Neuropharmacology Treating Rapid Cycling Bipolar Disorder with Novel Medications
Current Psychiatry Reviews Assessment of Organ Dysfunction and Underlying Causes in Maternal Near-miss Cases at Health Care Facilities in Doiwala Block of District Dehradun – A Retrospective Study
Current Hypertension Reviews Diabetes Mellitus: Novel Insights, Analysis and Interpretation of Pathophysiology and Complications Management with Imidazole-Containing Peptidomimetic Antioxidants
Recent Patents on Drug Delivery & Formulation AAV as An Immunogen
Current Gene Therapy Updates on the Synthetic Strategies and Structure-Activity Relationship of Anticonvulsant Benzothiazole and Benzimidazole Derivatives
Letters in Drug Design & Discovery Editorial: In Silico Studies in Drug Research Against Neurodegenerative Diseases
Current Neuropharmacology Gastrointestinal Immune System and Brain Dialogue Implicated in Neuroinflammatory and Neurodegenerative Diseases
Current Molecular Medicine Magnolia officinalis Reduces Inflammation and Damage Induced by Recurrent Status Epilepticus in Immature Rats
Current Pharmaceutical Design Combinatorics, Big Data, Neural Network & AI for Medicinal Chemistry & Drug Administration
Letters in Drug Design & Discovery Clinical Pharmacokinetics of Retigabine/Ezogabine
Current Clinical Pharmacology Sodium Channel Blockers as Therapeutic Target for Treating Epilepsy: Recent Updates
Current Topics in Medicinal Chemistry Elaboration and Validation of HPLC/DAD Method for Quality Control of Products Containing Cannabidiol
Current Pharmaceutical Analysis Nanoparticle- and Liposome-carried Drugs: New Strategies for Active Targeting and Drug Delivery Across Blood-brain Barrier
Current Drug Metabolism Theory and Application of Microdialysis in Pharmacokinetic Studies
Current Drug Metabolism Antiepileptics for Post-Traumatic Seizure Prophylaxis after Traumatic Brain Injury
Current Pharmaceutical Design Digital Intervention for the Management of Alzheimer’s Disease
Current Alzheimer Research Molecular Biology of T-Type Calcium Channels
CNS & Neurological Disorders - Drug Targets