Title: Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins
Volume: 8
Issue: 8
Author(s): Jin Zhang and Xinbin Chen
Affiliation:
Keywords:
p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay
Abstract: p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.
