Title:Epigallocatechin Gallate (EGCG) Mitigates Oxidative Stress and Restores Histological Integrity in Streptozotocin-Induced Zebrafish Model of Diabetes
Volume: 2
Author(s): Ajungla Jamir, Sentiyanger Longkumer and Prany Punj Pankaj*
Affiliation:
- Department of Zoology, Fish Biology and Fisheries Laboratory, Nagaland University, Lumami - 798 627, India
Keywords:
Antioxidant enzymes, Diabetic complications, Epigallocatechin gallate, Histopathological examinations, Oxidative stress, Zebrafish model.
Abstract:
Aims:
The primary aim of this study is to investigate the potential therapeutic effects of Epigallocatechin gallate (EGCG) in a zebrafish model of diabetes
induced by streptozotocin.
Background:
Diabetes mellitus is characterized by chronic organ dysfunction and failure. Natural compounds, particularly polyphenols such as EGCG present in
green tea, have garnered attention for their potential in managing various complications associated with diabetes owing to their antioxidant and
anti-inflammatory properties.
Objective:
This study seeks to evaluate the influence of EGCG on oxidative stress markers, antioxidant levels, and histopathological alterations in the liver,
kidney, and gills of zebrafish rendered diabetic through streptozotocin administration.
Methods:
Zebrafish subjects were allocated into four groups: control, diabetic, diabetic + EGCG, and control + EGCG. Superoxide dismutase (SOD) and
catalase (CAT) activities were quantified, and histopathological assessments were conducted on day 21 of the experimental period.
Results:
Diabetic zebrafish exhibited pronounced reductions in SOD and CAT activities relative to control counterparts, coupled with notable histological
changes indicative of organ impairment. Conversely, EGCG treatment attenuated oxidative stress bolstered antioxidant defenses and mitigated
histopathological abnormalities in the liver, kidney, and gills of diabetic zebrafish.
Conclusion:
EGCG exhibits promising therapeutic potential in safeguarding multiple organs against diabetes-induced injury, underscoring its significance in
ameliorating diabetic complications.
histopathological abnormalities in the liver, kidney, and gills of diabetic zebrafish.
Other:
These findings emphasize the importance of investigating natural compounds such as EGCG as potential therapeutic agents for managing diabetesrelated
complications. Further elucidation of the mechanistic underpinnings and clinical applicability of EGCG in diabetes management warrants
future research endeavors.
