Title:Therapeutic Effectiveness of Prunus dulcis for Nephroprotective and Hepatoprotective in Albino Mice
Volume: 2
Author(s): Rajesh Kumar Sharma*, Nidhi Jha, Anurag Mishra, Gamdur Singh, Madhvi Sanwelka and Ashish Gupta
Affiliation:
- Department of Pharmacology, NIMS Institute of Pharmacy, NIMS University Rajasthan, India
Keywords:
Prunus dulcis, Nephroprotective, Hepatoprotective, Serum creatinine, Nephrotoxicity, Acute hepatic impairments.
Abstract:
Background:
Nephrotoxicity caused by GM is a complicated occurrence that results in a variety of structural and functional changes, including lesions in the
glomerular region and proximal tubule damage, which leads to sudden kidney failure. The production of reactive oxygen species (ROS) has also
been linked to GM. Acute hepatic impairments caused by medication might lead to rapid deterioration of liver function.
Objective:
The purpose of this study was to evaluate the suspension of nuts of Prunus dulcis at a lower dose (800 mg/kg, b.w.) and a higher dose (1600
mg/kg, b.w.) for nephroprotective and hepatoprotective activities.
Materials and Methods:
Drug-induced nephrotoxicity and drug-induced hepatotoxicity models were used to evaluate the nephroprotective and hepatoprotective activity
using albino mice. A histopathological study was also performed.
Results:
Suspension of nuts Prunus dulcis exhibited significant nephroprotective and hepatoprotective activity. Suspension of nuts from Prunus dulcis at a
higher dose (1600 mg/kg b.w.) showed higher nephroprotective and hepatoprotective activity compared to the lower dose (800 mg/kg). The
nephroprotective activity was evident by decreased serum creatinine, uric acid, serum urea, and BUN, which were confirmed by histological study.
The hepatoprotective effect was confirmed by significantly decreased serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline
phosphatase (ALP), total protein, and total bilirubin levels in treated groups, which were further confirmed by histopathological study.
Conclusion:
The result suggests that Prunus dulcis possesses nephroprotective and hepatoprotective activities.
