Title:Comparative Study on the Genetic Architecture of Type 2 Diabetes in
Indian and Other Ethnic Groups: A Review
Volume: 21
Issue: 3
Author(s): Jyotsna Singh*, Vijay Tripathi, Nachimuthu Senthil Kumar, Rajiv Kant and Jonathan A. Lal
Affiliation:
- Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, India
Keywords:
Type 2 diabetes, genetics, candidate genes, genome-wide association scan, single nucleotide polymorphism, pandemic.
Abstract: Type 2 diabetes mellitus (T2DM) is a condition of metabolism that impacts
people worldwide regardless of country, age group, and gender. In addition to a sedentary
lifestyle, genetic susceptibility, specifically single nucleotide polymorphisms, is implicated
in the emergence and progression of T2DM. This study compares the genetic variants
of the Indian population with three other ethnic cohorts: African, European, and Chinese.
Based on the literature survey, common and unique Single Nucleotide Polymorphisms
(SNPs) and genes were explored in different Populations, including PPARG, TCF7L2,
THADA, CDKN2A, IGF2BP2, SLC30A8, HHEX and CDKAL1. Identifying common and
specific markers may help in risk prediction and early detection of T2DM. In conclusion,
this comparative study of T2DM-susceptible SNPs in Indian and other ethnic groups
highlights the complexity and diversity of genetic factors contributing to T2DM. By
shedding light on the similarities and disparities in genetic predisposition across populations,
this review contributes to the ongoing efforts to develop more effective and tailored
approaches for managing and avoiding T2DM in diverse global populations.
