Title:Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries
Volume: 25
Issue: 7
Author(s): Laith AL Eitan*, Iliya Yacoub Khair and Saif Alahmad
Affiliation:
- Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, 22110, Jordan
Keywords:
Pharmacogenetics, drug metabolizing enzymes, drug metabolism, polymorphisms, haplotype, genetic testing.
Abstract: Drug metabolizing enzymes play a crucial role in the pharmacokinetics and pharmacodynamics of
therapeutic drugs, influencing their efficacy and safety. This review explores the impact of genetic polymorphisms
in drug-metabolizing genes on drug response within Arab populations. We examine the genetic diversity
specific to Arab countries, focusing on the variations in key drug-metabolizing enzymes such as CYP450,
GST, and UGT families. The review highlights recent research on polymorphisms in these genes and their implications
for drug metabolism, including variations in allele frequencies and their effects on therapeutic outcomes.
Additionally, the paper discusses how these genetic variations contribute to the variability in drug response
and adverse drug reactions among individuals in Arab populations. By synthesizing current findings,
this review aims to provide a comprehensive understanding of the pharmacogenetic landscape in Arab countries
and offer insights into personalized medicine approaches tailored to genetic profiles. The findings underscore
the importance of incorporating pharmacogenetic data into clinical practice to enhance drug efficacy and
minimize adverse effects, ultimately paving the way for more effective and individualized treatment strategies
in the region.
