Title:A Literature-Based Study of Tardive Dyskinesia- From Pathogenesis to Treatment
Volume: 12
Author(s): Banjit Kalita, Tapash Chakraborty*, Shatabdi Ghose and Bhaskarjyoti Kalita
Affiliation:
- Department of Pharmaceutics,
Girijananda Chowdhury University, Assam, India
Keywords:
Tardive dyskinesia, movement disorder, dyskinesia, dopamine blockers, haloperidol, VMAT-2.
Abstract: Tardive dyskinesia (TD) is induced by antipsychotic drugs that have dopamineantagonising
properties. It frequently causes physical and mental anguish in individuals, lowering
their quality of life. Recent research on the aetiology and pathogenesis of TD indicates that genetic
predisposition, treatment options, age, sex, and lifestyle factors are among the key risk factors contributing
to the development of TD. Various genetic polymorphisms along with severe oxidative
stress and other diseased conditions help to precipitate TD while on antipsychotic medications or
other dopamine receptor blockers. Individuals diagnosed with schizophrenia are at a higher likelihood
of developing TD. The current piece of literature aims to review the probable underlying
mechanisms of TD, explore its pathophysiology, address the diagnostic challenges, and present the
available treatment options. This comprehensive analysis draws from a range of published peerreviewed
publications, presenting the information in a clear and accessible manner.
