Title:Exploring the Diverse Therapeutic Applications of 1, 3-Thiazine: A Comprehensive Review
Volume: 21
Issue: 2
Author(s): Neetu Agrawal*, Deepika Goyal and Shilpi Pathak
Affiliation:
- Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
Keywords:
Thiazine, heterocycle, biological activities, anticancer, antimicrobial, anti-inflammatory.
Abstract: Thiazine, a six-membered heterocycle containing nitrogen and sulfur atoms, is of paramount
importance due to its diverse biological functions and broad therapeutic effects. The pharmacological
attributes of 1,3-thiazine span a wide range of activities, including antileukemic, antimycobacterial,
anti-inflammatory, sedative, hypnotic, anti-influenza, antituberculosis, melanogenesis
inhibition, BACE1 inhibition (with anti-Alzheimer's potential), growth promotion, neuroprotective,
and anticonvulsant properties. Consequently, novel synthetic methodologies and the design of
new 1,3-thiazine derivatives are significantly influenced by recent research findings. This comprehensive
review explores both in vivo and in vitro preclinical studies on the biomedical and therapeutic
applications of 1,3-thiazine, highlighting its extensive medical relevance. It is anticipated
that derivatization strategies for 1,3-thiazine will open new avenues for the development of innovative
biological agents. This review aims to engage researchers, stimulating the creation of promising
new treatments and preventive measures for various diseases.
