Title:The Effect of Dapagliflozin on Heart Function in Animal Models of Cardiac Ischemia, A Systematic Review and Meta-analysis
Volume: 20
Issue: 1
Author(s): Tina Kianfar, Raquibul Hasan, Yaser Azizi*Fatemeh Ramezani*
Affiliation:
- Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
- Physiology Research Center, Iran University of
Medical Sciences, Tehran, Iran
Keywords:
Ischemic heart disease, dapagliflozin, DAPA, echocardiographic parameters, meta-analysis, animal models.
Abstract:
Introduction: In this study, a meta-analysis was conducted to investigate the therapeutic
effect of Dapagliflozin (DAPA) on animals suffering from myocardial ischemia reperfusion compared
to the group that did not receive treatment.
Methods: According to the inclusion and exclusion criteria two researchers performed the primary
and secondary screening based on the title abstract and full text. After data extraction, meta-analysis
was performed using STATA software. Standardized mean differences were used to analyze the results
of the reported studies. Subgroup analysis and quality control of articles were also conducted.
Results: A total of 21 separate experiments showed that DAPA increased mean fractional shortening
(%FS) and ejection fraction (%EF) compared to the untreated animals. A significant reduction
in the weight and size of the infarcted area and significant increases in dp/dt+, dp/dt-, left ventricular
end-systolic internal dimensions (LVIDs), left ventricular end-diastolic internal dimensions
(LVIDd), Volume systole and Volume diastole were observed in treated animals.
Conclusion: DAPA has the potential to become a candidate for the treatment of post-ischemic heart
damage, pending animal and human studies to validate this.
