Title:What are Proteome Atlases good for?
Volume: 2
Author(s): Amit Kumar Yadav*Suruchi Aggarwal
Affiliation:
- Computational and Mathematical Biology Centre (CMBC), Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd
Milestone, Faridabad-Gurgaon Expressway, Faridabad, Haryana-121001, India
- Center for Drug Discovery (CDD), Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-
Gurgaon Expressway, Faridabad, Haryana-121001, India
- Centre for Microbial Research (CMR), Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone,
Faridabad-Gurgaon Expressway, Faridabad, Haryana-121001, India
Keywords:
Proteome atlas, Proteoforms, Systems biology, Interactions, Mass spectrometry, Biomarkers, Drug target, Therapeutics.
Abstract: The technological advances in mass spectrometry and associated computational tools have enabled the development of proteome atlases and
comprehensive catalogs of proteome snapshots that have gradually transformed biomedical research. These proteome catalogs in specific
biological contexts, which focused initially on model organisms, have now expanded their scope to encompass diverse organisms, tissues, and
experimental conditions. These atlases, such as the Human Protein Atlas (HPA), Peptide Atlas, and Global Proteome Machine Database
(GPMDB), etc. provide invaluable insights into protein expression, subcellular localization, interactions, modifications, and functions. They aid in
understanding biological processes, identifying disease biomarkers, and discovering novel therapeutic targets. Despite their potential, proteome
atlases face challenges like data completeness, integration with other omics data, and ethical considerations. Addressing these challenges is vital
for further progress. Proteome atlases serve as indispensable resources, driving biomedical discovery and innovation.
