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Current Topics in Medicinal Chemistry

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ISSN (Online): 1873-4294

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Systematic Review Article

The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review

Author(s): Fabielle Marques-Santos, Robson Xavier Faria* and Maria Regina Reis Amendoeira

Volume 24, Issue 22, 2024

Published on: 28 June, 2024

Page: [1960 - 1999] Pages: 40

DOI: 10.2174/0115680266299409240606062235

Price: $65

Open Access Journals Promotions 2
Abstract

Introduction: Toxoplasmosis is a worldwide distributed zoonosis caused by Toxoplasma gondii (T. gondii), an obligate intracellular protozoan. The infection in immunocompetent hosts usually progresses with mild or no symptoms. However, in immunocompromised individuals, this disease can cause severe or fatal symptoms.

Method: Sulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological toxicity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone marrow suppression.

Results: The limited effect, significant toxicity, and emerging resistance to current drugs available to treat T. gondii infections require investigating other effective, nontoxic, and well-tolerated alternatives. Medicinal plants are, traditionally, the most promising sources used to treat infectious diseases

Conclusion: This review provides data on new therapeutic and prophylactic methods for T. gondii infection based on the use of extracts and/or compounds derived from natural products, which have been reported to be useful as alternative treatment options in the last 20 years.

Keywords: Toxoplasmosis, Plant extract, Toxicity, Phytotherapy, Toxoplasma gondii, Immunocompetent.

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