Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness

Title:Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness

Volume: 19 Issue: 4

Author(s): Tannaz Jamialahamdi, Matthew Kroh, Sorour Ashari, Wael Almahmeed, Ali Jangjoo, Luis E Simental-Mendía, Sepideh Salehabadi, Khalid Al-Rasadi and Amirhossein Sahebkar*

Affiliation:

• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Keywords: Hepatic stiffness, liver health, NAFLD, shear wave elastography, bariatric surgery, obesity.

Abstract:

Background: Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography.

Methods: A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model.

Results: The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%).

Conclusion: Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.

Cite this article as:

Jamialahamdi Tannaz, Kroh Matthew, Ashari Sorour, Almahmeed Wael, Jangjoo Ali, Simental-Mendía E Luis, Salehabadi Sepideh, Al-Rasadi Khalid and Sahebkar Amirhossein*, Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness, Reviews on Recent Clinical Trials 2024; 19 (4) . https://dx.doi.org/10.2174/0115748871303052240529102003