Cardioprotective Effects of Exercise: The Role of Irisin and Exosome

Yuehuan      Wang; Yi      Yang; Yanjuan      Song
doi:10.2174/0115701611285736240516101803
Abstract

Exercise is an effective measure for preventing and treating cardiovascular diseases, although the exact molecular mechanism remains unknown. Previous studies have shown that both irisin and exosomes can improve the course of cardiovascular disease independently. Therefore, it is speculated that the cardiovascular protective effect of exercise is also related to its ability to regulate the concentrations of irisin and exosomes in the circulatory system. In this review, the potential synergistic interactions between irisin and exosomes are examined, as well as the underlying mechanisms including the AMPK/PI3K/AKT pathway, the TGFβ1/Smad2/3 pathway, the PI3K/AKT/VEGF pathway, and the PTEN/PINK1/Parkin pathway are examined. This paper provides evidence to propose that exercise promotes the release of exosomes enriched with irisin, miR-486-5p and miR-342-5p from skeletal muscles, which results in the activation protective networks in the cardiovascular system. Moreover, the potential synergistic effect in exosomal cargo can provide new ideas for clinical research of exercise mimics.
Keywords: Exercise, cardiovascular disease, exosome, irisin, microRNAs, protective networks.
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DOI https://dx.doi.org/10.2174/0115701611285736240516101803	Print ISSN 1570-1611
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Current Vascular Pharmacology

Cardioprotective Effects of Exercise: The Role of Irisin and Exosome

Abstract

Graphical Abstract

TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE

Current Vascular Pharmacology

Cardioprotective Effects of Exercise: The Role of Irisin and Exosome

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE

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