Nucleobase and Peptide-based Designed Molecules for Biomedical Applications

Title:Nucleobase and Peptide-based Designed Molecules for Biomedical Applications

Volume: 2

Author(s): Shantanu Sen, Grace Kaul and Sandeep Verma*

Affiliation:

• Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India
• Mehta Family Center for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India
• Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India

Keywords: Peptide, Nucleobase, Bioinspired molecules, Bioactive molecule, Therapeutics, Antibiotic resistance.

Abstract:

Exploring a diverse range of bioinspired molecules is crucial for addressing real-world healthcare challenges and finding effective solutions. While numerous materials have been proposed and developed, their compatibility and stability within biological systems remain not fully understood and they are still undergoing extensive examination for their potential successful therapeutic translation. In this context, we aimed to provide an overview of bioinspired molecules that incorporate peptide as well as nucleobase-derived frameworks and explore their potential applications in the field of advanced therapeutics. Unlike many synthetic materials, these scaffolds exhibit remarkable biocompatibility, making them a promising avenue for addressing these concerns.

The increasing demand for alternative biocompatible materials stems from the necessity for therapeutic solutions to address diverse biological challenges. Therefore, compiling existing technologies may offer a comprehensive resource for researchers in this field.

In this review, special attention has been given to bioinspired molecules showcasing a diverse array of therapeutic functions, encompassing gasotransmitters delivery-mediated neuromodulation, sensing, and detection of important biological analytes, tissue engineering, anti-aggregating molecules, antibacterial compounds, anti-cancer molecules, etc.

This review has comprehensively summarized the design, practicality, and utilization of intriguing nucleobase or peptide-based bioinspired molecules for their potential advanced therapeutic applications. Significant constraints within current biocompatible materials continue to impede their potential for clinical translation and functional utilization. Hence, this review may inspire the readers to explore further significant findings in the field of novel bioinspired molecules’ synthesis and their potential therapeutic applicability.

Cite this article as:

Sen Shantanu, Kaul Grace and Verma Sandeep*, Nucleobase and Peptide-based Designed Molecules for Biomedical Applications, Current Indian Science 2024; 2 : e2210299X308571 . https://dx.doi.org/10.2174/012210299X308571240521052924