Title:The Synergistic Enhancement of Anti-Metabolic Diseases Function of
Morus alba with the Combination of Cha (Camellia sinensis)
Volume: 5
Author(s): Shinji Sato and Tetsuya Konishi*
Affiliation:
- Niigata University of Pharmacy and Applied Life Sciences, Akihaku, Niigata 956-0841, Japan
- Office HALD Food
Function Research, Yuzawa, 949-6103, Niigata, Japan
Keywords:
Anti-metabolic syndromes, synergistic effect, Morus alba, Camellia sinensis, Mibyou-care functional food, obesity.
Abstract:
Background: Functional foods play an important role in the prevention and amelioration
of metabolic syndromes leading to type 2 diabetes. Plant resources that have anti-metabolic
syndromes activity, such as Morus alba L. and Cha (Camellia sinensis L.), have been used in
functional foods against diabetes. Since Morus and Cha have different mechanisms of action
against metabolic syndromes, such as prevention of sugar uptake and lipidosis, respectively, the
combination of both resources will be a reliable approach for developing more efficient functional
food against type 2 diabetes because certain synergism is expected in their functions.
Methods: Male Wister Rats were fed the high fat-high sucrose (HFHS) diet for 12 weeks, with
and without supplementation of Morus and Cha alone and their combination, and the effect of
their supplementation on the markers of the metabolic syndrome such as obesity, lipidosis, and
fatty liver formation, were examined.
Results: Several metabolic syndrome markers, including body weight gain, lipid deposit, and
fatty liver formation, were more significantly prevented by the diet supplemented with Morus
and Cha combination compared to Morus or Cha given separately.
Conclusion: Appropriate formulation of food resources with different functional mechanisms is
a promising strategy for developing effective dietary treatment of type 2 diabetes that is a typical
Mibyou.
