Neuro-regeneration or Repair: Cell Therapy of Neurological Disorders as A Way Forward

Title:Neuro-regeneration or Repair: Cell Therapy of Neurological Disorders as A Way Forward

Volume: 22 Issue: 14

Author(s): Xiao-Yan Song, Cun-xiu Fan, Atta-ur Rahman, Muhammad Iqbal Choudhary and Xiao-Ping Wang*

Affiliation:

• Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

Keywords: Cell therapy, stem cells, Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Wilson’s disease, stroke, traumatic brain injury.

Abstract: The human central nervous system (CNS) has a limited capacity for regeneration and repair, as many other organs do. Partly as a result, neurological diseases are the leading cause of medical burden globally. Most neurological disorders cannot be cured, and primary treatments focus on managing their symptoms and slowing down their progression. Cell therapy for neurological disorders offers several therapeutic potentials and provides hope for many patients. Here we provide a general overview of cell therapy in neurological disorders such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Wilson’s disease (WD), stroke and traumatic brain injury (TBI), involving many forms of stem cells, including embryonic stem cells and induced pluripotent stem cells. We also address the current concerns and perspectives for the future. Most studies for cell therapy in neurological diseases are in the pre-clinical stage, and there is still a great need for further research to translate neural replacement and regenerative therapies into clinical settings.

Cite this article as:

Song Xiao-Yan, Fan Cun-xiu, Rahman Atta-ur, Choudhary Iqbal Muhammad and Wang Xiao-Ping*, Neuro-regeneration or Repair: Cell Therapy of Neurological Disorders as A Way Forward, Current Neuropharmacology 2024; 22 (14) . https://dx.doi.org/10.2174/1570159X22666240509092903