Effect of Rotenone on the Neurodegeneration among Different Models

doi:10.2174/0113894501281496231226070459
摘要

鱼藤酮是一种天然存在的植物产品，用作杀虫剂、杀虫剂和杀虫剂。它本质上是亲脂性的，可以穿过血脑屏障，诱导神经元变性。它抑制线粒体呼吸链复合体I并阻止电子的转移。它诱导ROS生成，从而损害线粒体活性。鱼藤酮是一种导致神经元死亡的有毒物质。本文综述了鱼藤酮对神经变性的影响，重点介绍了在细胞系、黑腹果蝇、小鼠和大鼠等多种实验模型上进行的行为、病理和神经病理成分的研究。
关键词: 鱼藤酮，杀虫剂，复合物-i抑制剂，神经变性，细胞系，果蝇，小鼠，大鼠。
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图形摘要

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DOI https://dx.doi.org/10.2174/0113894501281496231226070459	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592
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当代药物靶点

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