Title:Evaluating Ocular Blood Flow in Diabetic Macular Edema using Three-dimensional
Pseudocontinuous Arterial Spin Labeling
Volume: 20
Author(s): Jiao Sun, Huihui Wang and Yan-ling Wang*
Affiliation:
- Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Keywords:
Diabetic macular edema, Arterial spin labeling, Magnetic resonance imaging, Ocular blood flow, Retinopathy, Diabetes.
Abstract:
Background:
Alterations in ocular blood flow play an important role in the pathogenesis of diabetic macular edema; however, this remains unclear.
Objectives:
This study aimed to investigate ocular blood flow in eyes with or without diabetic macular edema using arterial spin labeling.
Methods:
This cross-sectional study included 118 eyes of 65 patients with diabetic retinopathy analyzed between November 2018 and December 2019. We
included a total of 53 eyes without diabetic macular edema (mean [SD] age, 57.83 [7.23] years; 29 men [54.7%]) and 65 eyes with diabetic
macular edema (mean [SD] age, 60.11 [7.63] years; 38 men [58.5%]). Using a 3.0-T magnetic resonance imaging, participants were imaged with
arterial spin labeling with multiple post-labeling delays.
Results:
The mean ocular blood flow at post-labeling delays of 1.5 and 2.5 s was significantly lower in eyes with diabetic macular edema among patients
with diabetic retinopathy compared with the remaining subgroups (P=0.022 and P <0.001, respectively). The mean ocular blood flow exhibited a
significant decrease in eyes with diabetic macular edema when the post-labeling delay was set at 2.5 s in the nonproliferative and proliferative
diabetic retinopathy groups, compared with the remaining subgroups (P=0.005 and P=0.002, respectively). The cutoff points of ocular blood flow
at post-labeling delays of 1.5 s and 2.5 s were 9.40 and 11.10 mL/100 g/min, respectively.
Conclusion:
Three-dimensional pseudocontinuous arterial spin labeling can identify differences in the ocular blood flow of patients with diabetic eyes with and
without diabetic macular edema.
