Title:A Review on Lipid-based Nanoformulations for Targeting Brain through Non-invasive Nasal Route
Volume: 13
Issue: 1
Author(s): Nirvesh Chaudhri*, Vaibhav Rastogi and Anurag Verma
Affiliation:
- Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
Keywords:
Nasal mucosa, nasal route, nanostructured lipid carrier (NLC), non-invasive, antipsychotic, brain targeting.
Abstract: The nasal method for administering nanoformulations to the brain has been examined and
proven successful by prior investigators. For the treatment of central nervous system (CNS) disorders
such as neuropsychiatric, depression, Alzheimer and anxiety, intranasal administration has become
more popular for delivering drugs to the brain. This method offers direct transport through neuronal
pathways. The lipid-based nanocarriers like nanostructured lipid carriers (NLC) appear more favorable
than other nanosystems for brain administration. The nanostructured lipid carriers (NLC) system
can quickly transform into a gelling system to facilitate easy administration into the nasal passages.
The various compatibility studies showed that the other lipid structured-based formulations may not
work well for various reasons, including a low drug filing capacity; during storage, the formulation
showed changes in the solid lipid structures, which gives a chance of medication ejection. Formulations
containing NLC can minimize these problems by improving drug solubility and permeation rate
by incorporating a ratio of liquid lipids with solid lipids, resulting in improved stability during storage
and drug bioavailability because of the higher drug loading capacity. This review aimed to find
and emphasize research on lipid-based nanocarrier formulations that have advanced the treatment of
central nervous system illnesses using nasal passages to reach the targeted area's drug molecules.
