Title:[Cu(dimethylbpy)2Cl]PF6 Complex as an Antibacterial Agent
Volume: 22
Issue: 5
Author(s): Naghmeh Satarzadeh, Ali Asadipour and Bagher Amirheidari*
Affiliation:
- Department
of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
- Pharmaceutical
Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
Keywords:
Antibacterial activity, copper, Cu complex, gram-negative bacteria, gram-positive bacteria, antibacterial agent.
Abstract:
Background: Antibiotic resistance is currently considered a major public health problem.
This subject underscores the critical need for novel and enhanced antibacterial agents with
a novel molecular structure and a new target to prevent cross-resistance. Copper exhibits antimicrobial
properties by disrupting bacterial cell membranes and interfering with cellular processes.
Copper complexes enhance these properties, offering improved stability and targeted
antibacterial activity. Their ability to release copper ions can gradually enhance efficacy while
minimizing toxicity. Therefore, investigating the antibacterial properties of new copper complexes
is of significance.
Methods: In this study, the antibacterial activity of [Cu(dimethylbpy)2Cl]PF6 complex was examined
against several Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli,
klebsiella pneumoniae, salmonella typhi and Gram-positive bacteria Staphylococcus aureus and
Micrococcus luteus by determining the minimum inhibitory concentration (MIC). The antibacterial
activity of [Cu(dimethylbpy)2Cl]PF6 complex and Gentamicin (as standard compound)
were determined using the microplate method. All concentrations were repeated three times. The
minimum inhibitory concentration was determined both using the unaided eye and absorbance
at 490 nm.
Results: The [Cu(dimethylbpy)2Cl]PF6 complex showed higher antibacterial activity against
Gram-positive bacteria than Gram-negative bacteria. Among the assayed bacterial strains, the
complex was most effective against Micrococcus luteus and Staphylococcus aureus with MIC
values of 100 and 250 μM, respectively.
Conclusion: This complex displayed antimicrobial potential against some bacterial strains.
Therefore, this complex may be used as an effective antibacterial agent in the treatment of infection
caused by some bacterial strains, but further research is needed.