Title:Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models
Volume: 20
Issue: 1
Author(s): Isa Mahendra*, Ahmad Kurniawan, Muhamad Basit Febrian, Iim Halimah, Asep Rizaludin and Dani Gustaman Syarif
Affiliation:
- Research Center for Radioisotope, Radiopharmaceuticals and Biodosimetry Technology, National Research and Innovation
Agency, Serpong, Indonesia
Keywords:
Lung cancer, animal model, allograft, cell-derived allograft, xenograft animals, GEMM.
Abstract:
Background: The use of appropriate animal models for cancer studies is a major challenge,
particularly for investigators who lack the resources to maintain and use xenograft animals or
genetically engineered mouse models (GEMM). In addition, several countries intending to incorporate
these models must conduct importation procedures, posing an additional challenge.
Objective: This review aimed to explore the use of cell-derived allograft or syngeneic models under
limited resources. The results can be used by investigators, specifically from low-middle-income
countries, to contribute to lung cancer eradication.
Methods: A literature search was carried out on various databases, including PubMed, Web of Science,
and Scopus. In addition, the publication year of the selected articles was set between 2013 and
2023 with different search components (SC), namely lung cancer (SC1), animal models (SC2), and
preclinical studies (SC3).
Results: This systematic review focused on selecting animals, cells, and methods that could be applied
to generating allograft-type lung cancer animal models from 101 included articles.
Conclusion: Based on the results, the use of cell-derived allograft models in cancer studies is feasible
and relevant, and it provides valuable insights regarding the conditions with limited resources.
