Antioxidative and Anti-inflammatory Effects of Plant-derived
Hypoglycemic Medicines: An  In vivo/In vitro Systematic Review

Mohammad   Sadegh   Adel-Mehraban; Ozra      Tabatabaei-Malazy; Azadeh      Manayi; Sudabeh      Alatab; Shahrzad      Mohseni; Saeed   Ebrahimi   Fana; Pooria      Asili; Roodabeh      Bahramsoltani; Fataneh      Esmaeili; Bayan      Azizi
doi:10.2174/0115680266295032240415064750
Abstract

Background: The activation of oxidative stress and inflammatory conditions has been associated with acceleration in diabetes (DM) onset and complications. Despite various anti-DM medications, there is a growing trend to discover inexpensive and effective treatments with low adverse effects from plants as one of the promising sources for drug development.
Objective: This study aimed to systematically investigate the simultaneous anti-inflammatory and antioxidant effects of plant-derived hypoglycemic medicines in diabetic experimental models.
Methods: The search terms consisted of “diabetes”, “herbal medicine”, “antioxidant”, “Inflammatory biomarker”, and their equivalents among PubMed, Scopus, Web of Science, and Cochrane Library databases up to 17 August 2021.
Results: Throughout the search of databases, 201 eligible experimental studies were recorded. The results showed that the most commonly assessed inflammatory and oxidative stress biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL) 6, IL-1β, IL-10, malondialdehyde (MDA), and nitric oxide (NO). The activity of antioxidant enzymes, including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) were assessed in the present review. Among herbal treatments, Trigonella foenum-graecum L., Centella asiatica (L.) Urb., Vitis vinifera L., and Moringa oleifera Lam. were most commonly used for diabetic complications. Due to the dispersion of the treatments, meta-analysis was not applicable.
Conclusion: Our findings showed that the application of different plant-derived hypoglycemic treatments in animal models improved diabetes and its complications, as well as modulated concomitant inflammatory and oxidative stress biomarkers. These findings suggest that plant-based antidiabetic medicines and food supplements have the potential to manage diabetes and its complications.
Keywords: Diabetes mellitus, Phytotherapy, Animal models, Oxidative stress, Anti-inflammatory biomarkers, Hyperglycemia, Herbal medicine.
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DOI https://dx.doi.org/10.2174/0115680266295032240415064750	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294
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