Title:Prospects of Targeted Gene/Drug Delivery Vectors and their Potential Use in
Cancer Therapy
Volume: 2
Author(s): Venkanna Muripiti, Venkatesh Ravula and Srilakshmi V. Patri*
Affiliation:
- Department of Chemistry, National Institute of Technology, Warangal-506004, Telangana, India
Keywords:
Gene therapy, Targeted receptors, Off-target, Cancer therapy, Dual-targeting, Drug delivery vector.
Abstract: Targeted gene and drug delivery vector developments have completely changed the therapeutic intervention by providing previously unheard-of
levels of accuracy and efficacy in treating various illnesses. Cancer is one such fatal disease plaguing people across the globe. This review article
highlights the potential uses of targeted delivery systems in the field of cancer treatment while providing a thorough examination of the state of the
art. Chemotherapy and radiation therapy are being used to cure cancer, yet they can be frequently ineffective and have serious adverse effects.
Novel techniques for therapy have to be designed. Existing chemotherapy is being superseded by particular gene therapy used for genetic diseases.
Therefore, to deliver the therapeutic agent to the targeted place, a carrier or vector is needed. The current review is focused on targeted gene/drug
delivery vectors concerning i) cationic lipids that target single receptors ii) ligand-peptide conjugated cationic lipids iii) modalities for targeting
dual ligands for cancer therapy iv) passive versus active targeting v) properties of nano-formulations for gene and drug delivery. The most recent
developments in lipid customization for certain receptors overexpressed in cancer cells are covered to reduce side effects and improve treatment
results. By delving into the above areas, this review presents a broad overview of the changing field of cationic lipids in cancer therapy, giving
scientists and medical professionals insightful knowledge about the many strategies for ensuring precise and efficient drug delivery in the battle
against cancer.
