Title:Revealing the Potential of Mucoadhesive Ocular Nanoparticles for Enhanced Drug Delivery
Volume: 15
Issue: 2
Author(s): Shubhrat Maheshwari, Aditya Singh, Rufaida Wasim, Bhupendra G. Prajapati*, Rishabha Malviya and Gamal A. Shazly
Affiliation:
- Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat 384012 India
Keywords:
Ocular drug delivery system , diabetic macular edema , bioadhesive , intraocular tissue , bioavailability , diabetic retinopathy
Abstract: An ocular drug delivery system, or ODDS, is the method for executing a prescription to
the peeper in order to treat or manage conditions related to the eyes. The range of ODDS modalities
is broad and includes simple aseptic eye drops for the optic surface as well as complex implants
for intraocular tissue. The use of ODDS is often necessary for states such as cataracts, progressive
retinal illness, inflammation, dry eye syndrome, diabetic retinopathy (DR), and other related
diseases or disorders. To sustain the intended drug concentrations at the prescribed place,
new drug delivery technologies have been developed, incorporating fibrin-sealing materials and
sticky gels. The advancement of long-lasting drug delivery systems that are non-invasive and applied
externally to the back portion of the eye possesses the potential to improve drug administration
significantly. The progress made in the field of ophthalmic drug delivery has resulted in
promising advancements in the treatment of diseases affecting both the front and back portions of
the eye. These groundbreaking strategies for administering medication hold immense potential for
enhancing drug delivery in the future. Furthermore, these inventive devices and/or formulations
are easy to develop, causing minimal or negligible irritation, boasting a prolonged period residing
in front of the cornea, sustaining the release of drugs, and increasing the therapeutic availability of
medications within the eye. To remain up to date with the current advancements in the field of ocular
drug delivery, it is essential to acquire the latest information. This helps drug delivery scientists
improve their thought processes and also makes it possible to create fresh, trustworthy drug
delivery methods. The objective of this investigation is to provide a thorough investigation while
also tracking their advancement. Next, we shall examine the latest breakthroughs in formulation innovations
based on nanotechnology. We will also discuss the most recent developments in additional
ocular medication administration methods, including in-situ gels, implants, contact lenses, and
microneedles.
