Title:Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier
in Cancer Therapy
Volume: 31
Issue: 4
Author(s): Dilpreet Singh*, Lalu Muhammad Irham, Amrinder Singh and Balak Das Kurmi
Affiliation:
- University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, 140413, India
- University Centre
for Research and Development, Chandigarh University, Gharuan (140413), India
Keywords:
Cancer, dendrimers, guanidinium, cargo molecules, cytotoxicity, nanocarrier.
Abstract: The landscape of cancer therapy has witnessed a paradigm shift with the emergence of
innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard
in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility,
these dendrimers offer a promising avenue for the targeted delivery of therapeutic
cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium-
based Peptide Dendrimers, unraveling their structural intricacies, mechanisms of action, and
advancements that have propelled them from laboratory curiosities to potential clinical champions.
Exploiting the potent properties of guanidinium, these dendrimers exhibit unparalleled precision
in encapsulating and transporting diverse cargo molecules, ranging from conventional chemotherapeutics
to cutting-edge nucleic acids. The review navigates the depths of their design principles,
investigating their prowess in traversing the complex terrain of cellular barriers for optimal
cargo delivery. Moreover, it delves into emerging trends, such as personalized therapeutic approaches,
multimodal imaging, and bioinformatics-driven design, highlighting their potential to redefine
the future of cancer therapy. Crucially, the review addresses the pivotal concerns of biocompatibility
and safety, examining cytotoxicity profiles, immune responses, and in vivo studies. It underscores
the importance of aligning scientific marvels with the stringent demands of clinical applications.
Through each section, the narrative underscores the promises and possibilities that
Guanidinium-based Peptide Dendrimers hold and how they can potentially reshape the landscape
of precision cancer therapy.
