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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Zn[L-proline]2 as an Efficient Catalyst for the Synthesis of Dihydro Pyrano Thiazole Derivatives via Cycloaddition Reaction in Aqueous Medium

Author(s): Hany M. Abd El-Lateef*, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf and Mahmoud Abd El Aleem Ali Ali El-Remaily*

Volume 28, Issue 9, 2024

Published on: 15 April, 2024

Page: [700 - 707] Pages: 8

DOI: 10.2174/0113852728295316240325041145

Abstract

In the current study, a zinc-linked amino acid complex was successfully synthesized as an efficient and recoverable catalyst for the synthesis of dihydro pyrano thiazole derivatives via the reaction of an aromatic aldehyde with malononitrile and rhodanine in one-pot, three-component reaction under green conditions. The structures of the new compounds were elucidated by elemental and spectral analyses. Environmental friendliness, low cost, operational simplicity, extensive reusability and applicability, and easy recovery of the catalyst using simple methods are the critical features of this methodology. Moreover, a series of dihydro pyrano thiazole derivatives were synthesized. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, short reaction time, excellent yields, and high purity without using any hazardous solvents.

Keywords: Zinc-linked amino acid complex, dihydro pyrano thiazole, low cost, operational simplicity, cycloaddition reaction, aqueous medium.

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