Title:Decreased Cerebral Perfusion in Chronic Migraine: A Voxel-based Cerebral
Blood Flow Analysis Using 3D Pseudo-continuous Arterial Spin Labeling
Volume: 20
Author(s): Xin Li, Mengqi Liu, Shuqiang Zhao and Zhiye Chen*
Affiliation:
- Department of Radiology, Hainan Hospital of PLA General Hospital, Sanya 572013, China
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
Keywords:
Arterial spin labeling, Brain, Chronic migraine, Gray matter, Voxel-based analysis, White matter fibers.
Abstract:
Background:
A contrast agent-free approach would be preferable to the frequently used invasive approaches for evaluating cerebral perfusion in chronic
migraineurs (CM). In this work, non-invasive quantitative volumetric perfusion imaging was used to evaluate alterations in cerebral perfusion in
CM.
Methods:
We used conventional brain structural imaging sequences and 3D pseudo-continuous arterial spin labeling (3D PCASL) to examine thirteen CM
patients and fifteen normal controls (NCs). The entire brain gray matter underwent voxel-based analysis, and the cerebral blood flow (CBF) values
of the altered positive areas were retrieved to look into the clinical variables' significant correlation.
Results:
Brain regions with the decreased perfusion were located in the left postcentral gyrus, bilateral middle frontal gyrus, left middle occipital gyrus, left
superior parietal lobule, left medial segment of superior frontal gyrus, and right orbital part of the inferior frontal gyrus. White matter fibers with
decreased perfusion were located in bilateral superior longitudinal tracts, superior corona radiata, external capsules, anterior and posterior limbs of
the internal capsule, anterior corona radiata, inferior longitudinal fasciculus, and right corticospinal tract. However, the correlation analysis showed
no significant correlation between the CBF value of the above positive brain regions with clinical variables (p > 0.05).
Conclusion:
The current study provided more useful information to comprehend the pathophysiology of CM and revealed a new insight into the neural
mechanism of CM from the pattern of cerebral hypoperfusion.
