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ISSN (Online): 1873-4286

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Review Article

Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights

Author(s): Atena Soleimani, Nikoo Saeedi, Abdulridha Mohammed Al-Asady, Elnaz Nazari, Reyhane Hanaie, Majid Khazaei, Elnaz Ghorbani, Hamed Akbarzade, Mikhail Ryzhikov, Amir Avan and Seyed Mahdi Hasanian Mehr*

Volume 30, Issue 18, 2024

Published on: 15 April, 2024

Page: [1386 - 1397] Pages: 12

DOI: 10.2174/0113816128291321240329050945

Price: $65

Abstract

Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markers cancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.

Keywords: LGR5, ALDH, CD166, CD133, CD44, cancer stem cell, colon cancer.

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