Title:Efficacy and Safety of Stem Cell Therapy in Alzheimer's Disease: A Review
Volume: 20
Issue: 2
Author(s): Deepshi Arora, Dhruv Gupta, Deeksha, Yugam Taneja and Ashwani K. Dhingra*
Affiliation:
- Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, 135001, India
Keywords:
Alzheimer's, β-amyloid, embryonic, pluripotent, mesenchymal, regeneration, neurotrophy, stem cells.
Abstract: Alzheimer's disease (AD) prevalence is a significant public health concern. Tau tangle
buildup and different metabolic abnormalities are the primary neuropathological alterations that
lead to this illness. Currently, there is a lack of effective treatment for patients with AD due to the
complexity of the disease and the lack of a clear understanding of its aetiology. However, stem
cell therapy can potentially be used to replace lost neuronal cells. Although this technology is only
in its initial stages, it has the potential to transform the treatment of this condition. AD is amenable
to disease-modifying treatment with stem cell therapy. Since the early 2000s, there have been
more investigations on stem cells, including Mesenchymal Stem Cells (MSCs) and Neural Stem
Cells (NSCs), as a result of the failure to produce new medicines for AD. Numerous animal
studies have investigated issues relating to stem cells, such as their origin, ability to differentiate,
how they are cultured, how they form tumours, how they are injected, and how mobile they are.
Clinical trials to test the use of stem cells for AD have been underway since 2010, primarily in
East Asia. Although there were no significant immediate or long-term side effects, two phase I investigations
on moderate AD have been completed. Neither of these studies revealed any considerable
clinical efficacy. Numerous investigations with more complex study designs, established levels,
and biomarkers, such as amyloid positron emission tomography among people with mild to
moderate AD, are in the works. Stem cell therapy for AD has the potential to alter the condition.
The methods of action, preclinical animal studies, human clinical trials, and challenges stem cell
therapy for AD faces are all covered in this article. We will also go over current advancements in
stem cell research and the pathophysiology of AD, as well as challenges and solutions for employing
cell-based therapeutics for AD and associated conditions.
