Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases

Title:Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases

Volume: 17 Issue: 3

Author(s): Shefilyn Widjaja, Radiana Dhewayani Antarianto and Novi Silvia Hardiany*

Affiliation:

• Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Keywords: Non-communicable diseases, ageing, PGC-1α, caloric restriction, fasting, metabolic disease, oxidative damage.

Abstract: Ageing is the most significant risk factor for a number of non-communicable diseases, manifesting as cognitive, metabolic, and cardiovascular diseases. Although multifactorial, mitochondrial dysfunction and oxidative stress have been proposed to be the driving forces of ageing. Peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) is a transcriptional coactivator central to various metabolic functions, of which mitochondrial biogenesis is the most prominent function. Inducible by various stimuli, including nutrient limitations, PGC-1α is a molecule of interest in the maintenance of mitochondrial function and, therefore, the prevention of degenerative diseases. This review involves a literature search for articles retrieved from PubMed using PGC-1α, ageing, and dietary restriction as keywords. Dietary restriction has been shown to promote tissue-specific PGC-1α expression. Both dietary restriction and PGC-1α upregulation have been shown to prolong the lifespans of both lower and higher-level organisms; the incidence of non-communicable diseases also decreased in fasting mammals. In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.

Cite this article as:

Widjaja Shefilyn, Antarianto Dhewayani Radiana and Hardiany Silvia Novi*, Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases, Current Aging Science 2024; 17 (3) . https://dx.doi.org/10.2174/0118746098301226240402051508